U.S. BRAND NAMES — Epiduo™
PHARMACOLOGIC CATEGORY
Acne Products
Topical Skin Product
Topical Skin Product, Acne
DOSING: ADULTS — Acne vulgaris: Topical: Apply once daily to affected areas after skin has been cleaned and dried
DOSING: PEDIATRIC — Children ≥ 12 years: Refer to adult dosing.
DOSING: ELDERLY — Refer to adult dosing.
DOSAGE FORMS — Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Gel, topical:
Epiduo™ : Adapalene 0.1% and benzoyl peroxide 2.5% (45 g)
DOSAGE FORMS: CONCISE
Gel, topical:
Epiduo™ : Adapalene 0.1% and benzoyl peroxide 2.5% (45 g)
GENERIC EQUIVALENT AVAILABLE — No
ADMINISTRATION — Apply a pea-sized amount for each area of the face (eg, forehead, chin, each cheek). Skin should be clean and dry before applying. For external use only; avoid applying to eyes and mucous membranes.
USE — Topical treatment of acne vulgaris
ADVERSE REACTIONS SIGNIFICANT
>10%: Dermatologic: Dry skin (<1% to 14%)
1% to 10%: Dermatologic: Scaling (<1% to 9%), erythema (1% to 8%), burning (1% to 7%), stinging (1% to 7%), contact dermatitis (3%), skin irritation (1%)
CONTRAINDICATIONS — There are no contraindications listed in the manufacturer's labeling.
WARNINGS / PRECAUTIONS
Concerns related to adverse effects: Bleaching effects: May bleach hair or colored fabric. Photosensitivity: Use is associated with increased suspectibility/sensitivity to UV light; avoid sunlamps or excessive sunlight exposure. Daily sunscreen use and other protective measures are recommended. Skin irritation: Certain cutaneous signs and symptoms (eg, erythema, dryness, scaling, burning/stinging) may occur during treatment; these are most likely to occur during the first 4 weeks and usually lessen with continued use. Use of moisturizer, decreased use, or discontinuation may be recommended.
Concurrent drug therapy issues: Topical acne product: Use concomitant topical acne therapy with caution; cumulative irritancy may occur.
Special populations: Pediatrics: Safety and efficacy have not been established in children <12 years of age.
Other warnings/precautions: Appropriate use: For external use only; avoid contact with abraded skin, mucous membranes, and eyes.
DRUG INTERACTIONS
Vitamin A: May enhance the adverse/toxic effect of Retinoid-like Compounds. Risk D: Consider therapy modification
PREGNANCY RISK FACTOR — C (show table)
PREGNANCY IMPLICATIONS — There are no well-controlled studies in pregnant women. Use only if benefit outweighs the potential risk to fetus.
LACTATION — Excretion in breast milk unknown/use caution
MECHANISM OF ACTION
Benzoyl peroxide releases free-radical oxygen which oxidizes bacterial proteins in the sebaceous follicles decreasing the number of anaerobic bacteria and decreasing irritating-type free fatty acids.
Adapalene is a retinoid-like compound which is a modulator of cellular differentiation, keratinization, and inflammatory processes, all of which represent important features in the pathology of acne vulgaris.
PHARMACODYNAMICS / KINETICS
Absorption: Via the skin
Metabolism: Benzoyl peroxide: Converted to benzoic acid in skin
Excretion: Adapalene: Primarily through bile; Benzoyl peroxide: Urine
Showing posts with label Adapalene and benzoyl peroxide. Show all posts
Showing posts with label Adapalene and benzoyl peroxide. Show all posts
Monday, May 24, 2010
Adapalene and benzoyl peroxide
U.S. BRAND NAMES — Epiduo™
PHARMACOLOGIC CATEGORY
Acne Products
Topical Skin Product
Topical Skin Product, Acne
DOSING: ADULTS — Acne vulgaris: Topical: Apply once daily to affected areas after skin has been cleaned and dried
DOSING: PEDIATRIC — Children ≥ 12 years: Refer to adult dosing.
DOSING: ELDERLY — Refer to adult dosing.
DOSAGE FORMS — Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Gel, topical:
Epiduo™ : Adapalene 0.1% and benzoyl peroxide 2.5% (45 g)
DOSAGE FORMS: CONCISE
Gel, topical:
Epiduo™ : Adapalene 0.1% and benzoyl peroxide 2.5% (45 g)
GENERIC EQUIVALENT AVAILABLE — No
ADMINISTRATION — Apply a pea-sized amount for each area of the face (eg, forehead, chin, each cheek). Skin should be clean and dry before applying. For external use only; avoid applying to eyes and mucous membranes.
USE — Topical treatment of acne vulgaris
ADVERSE REACTIONS SIGNIFICANT
>10%: Dermatologic: Dry skin (<1% to 14%)
1% to 10%: Dermatologic: Scaling (<1% to 9%), erythema (1% to 8%), burning (1% to 7%), stinging (1% to 7%), contact dermatitis (3%), skin irritation (1%)
CONTRAINDICATIONS — There are no contraindications listed in the manufacturer's labeling.
WARNINGS / PRECAUTIONS
Concerns related to adverse effects: Bleaching effects: May bleach hair or colored fabric. Photosensitivity: Use is associated with increased suspectibility/sensitivity to UV light; avoid sunlamps or excessive sunlight exposure. Daily sunscreen use and other protective measures are recommended. Skin irritation: Certain cutaneous signs and symptoms (eg, erythema, dryness, scaling, burning/stinging) may occur during treatment; these are most likely to occur during the first 4 weeks and usually lessen with continued use. Use of moisturizer, decreased use, or discontinuation may be recommended.
Concurrent drug therapy issues: Topical acne product: Use concomitant topical acne therapy with caution; cumulative irritancy may occur.
Special populations: Pediatrics: Safety and efficacy have not been established in children <12 years of age.
Other warnings/precautions: Appropriate use: For external use only; avoid contact with abraded skin, mucous membranes, and eyes.
DRUG INTERACTIONS
Vitamin A: May enhance the adverse/toxic effect of Retinoid-like Compounds. Risk D: Consider therapy modification
PREGNANCY RISK FACTOR — C (show table)
PREGNANCY IMPLICATIONS — There are no well-controlled studies in pregnant women. Use only if benefit outweighs the potential risk to fetus.
LACTATION — Excretion in breast milk unknown/use caution
MECHANISM OF ACTION
Benzoyl peroxide releases free-radical oxygen which oxidizes bacterial proteins in the sebaceous follicles decreasing the number of anaerobic bacteria and decreasing irritating-type free fatty acids.
Adapalene is a retinoid-like compound which is a modulator of cellular differentiation, keratinization, and inflammatory processes, all of which represent important features in the pathology of acne vulgaris.
PHARMACODYNAMICS / KINETICS
Absorption: Via the skin
Metabolism: Benzoyl peroxide: Converted to benzoic acid in skin
Excretion: Adapalene: Primarily through bile; Benzoyl peroxide: Urine
PHARMACOLOGIC CATEGORY
Acne Products
Topical Skin Product
Topical Skin Product, Acne
DOSING: ADULTS — Acne vulgaris: Topical: Apply once daily to affected areas after skin has been cleaned and dried
DOSING: PEDIATRIC — Children ≥ 12 years: Refer to adult dosing.
DOSING: ELDERLY — Refer to adult dosing.
DOSAGE FORMS — Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Gel, topical:
Epiduo™ : Adapalene 0.1% and benzoyl peroxide 2.5% (45 g)
DOSAGE FORMS: CONCISE
Gel, topical:
Epiduo™ : Adapalene 0.1% and benzoyl peroxide 2.5% (45 g)
GENERIC EQUIVALENT AVAILABLE — No
ADMINISTRATION — Apply a pea-sized amount for each area of the face (eg, forehead, chin, each cheek). Skin should be clean and dry before applying. For external use only; avoid applying to eyes and mucous membranes.
USE — Topical treatment of acne vulgaris
ADVERSE REACTIONS SIGNIFICANT
>10%: Dermatologic: Dry skin (<1% to 14%)
1% to 10%: Dermatologic: Scaling (<1% to 9%), erythema (1% to 8%), burning (1% to 7%), stinging (1% to 7%), contact dermatitis (3%), skin irritation (1%)
CONTRAINDICATIONS — There are no contraindications listed in the manufacturer's labeling.
WARNINGS / PRECAUTIONS
Concerns related to adverse effects: Bleaching effects: May bleach hair or colored fabric. Photosensitivity: Use is associated with increased suspectibility/sensitivity to UV light; avoid sunlamps or excessive sunlight exposure. Daily sunscreen use and other protective measures are recommended. Skin irritation: Certain cutaneous signs and symptoms (eg, erythema, dryness, scaling, burning/stinging) may occur during treatment; these are most likely to occur during the first 4 weeks and usually lessen with continued use. Use of moisturizer, decreased use, or discontinuation may be recommended.
Concurrent drug therapy issues: Topical acne product: Use concomitant topical acne therapy with caution; cumulative irritancy may occur.
Special populations: Pediatrics: Safety and efficacy have not been established in children <12 years of age.
Other warnings/precautions: Appropriate use: For external use only; avoid contact with abraded skin, mucous membranes, and eyes.
DRUG INTERACTIONS
Vitamin A: May enhance the adverse/toxic effect of Retinoid-like Compounds. Risk D: Consider therapy modification
PREGNANCY RISK FACTOR — C (show table)
PREGNANCY IMPLICATIONS — There are no well-controlled studies in pregnant women. Use only if benefit outweighs the potential risk to fetus.
LACTATION — Excretion in breast milk unknown/use caution
MECHANISM OF ACTION
Benzoyl peroxide releases free-radical oxygen which oxidizes bacterial proteins in the sebaceous follicles decreasing the number of anaerobic bacteria and decreasing irritating-type free fatty acids.
Adapalene is a retinoid-like compound which is a modulator of cellular differentiation, keratinization, and inflammatory processes, all of which represent important features in the pathology of acne vulgaris.
PHARMACODYNAMICS / KINETICS
Absorption: Via the skin
Metabolism: Benzoyl peroxide: Converted to benzoic acid in skin
Excretion: Adapalene: Primarily through bile; Benzoyl peroxide: Urine
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